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The purpose of this study is to evaluate whether zilebesiran versus placebo reduces the risk of cardiovascular (CV) death, nonfatal myocardial infarction (MI), nonfatal stroke, or heart failure (HF) events. This is an event-driven study that will continue until the targeted number of positively adju…

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📍 Nearest site: Hutchinson, Kansas, United States — 36 km away · 1,153 sites in total

The field of transcatheter tricuspid valve replacement (TTVR) is rapidly emerging and data on this topic are scarce. Particularly, little is known about which patients are at greatest risk of procedural complications, such as the timing and onset of conduction disturbances necessitating permanent pa…

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 31 sites in total

Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF. The study will include an optional pre-screenin…

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 957 sites in total

This is a Phase III, randomized, double-blind, parallel-group, placebo-controlled, multicenter study to investigate CV outcomes with elecoglipron compared with placebo, in adults with heart failure with preserved ejection fraction (HFpEF)/heart failure with mildly reduced ejection fraction (HFmrEF),…

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 672 sites in total

This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before they start on the study. The purpose of this study is to find out…

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 588 sites in total · contact listed

The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4/X4S Transcatheter Heart Valve (THV) in subjects with symptomatic, severe, calcific aortic stenosis (AS).

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 65 sites in total

A prospective, multinational, randomized, double-blind, clinical trial evaluating the safety and effectiveness of a novel atrioventricular interval modulation (AVIM) algorithm downloaded into a dual-chamber Medtronic Astra/Azure pacemaker.

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 131 sites in total

The purpose of this phase 3, randomized, placebo controlled, event-driven study is to assess the effect of AZD0780, an oral PCSK9 inhibitor, compared with placebo in reducing the risk of MACE-PLUS in patients with established ASCVD or at high risk for a first ASCVD event. The effect of AZD0780 vs pl…

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 1,452 sites in total

This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether vicadrostat (BI 690517) in combination with empag…

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 652 sites in total · contact listed

The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).

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📍 Nearest site: Hutchinson, Kansas, United States — 36 km away · 252 sites in total

The purpose of this extension study is to collect additional safety and efficacy on QCZ484 for hypertensive patients who successfully completed the parent study, CQCZ484A12201 or additional QCZ484 studies as specified in the respective parent study protocols.

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 25 sites in total · contact listed

A prospective, multi-center, single-blind, randomized (1:1), non-inferiority study comparing clinical outcomes of the Virtue® Sirolimus AngioInfusion™ Balloon (SAB) to the AGENT™ Paclitaxel Drug-Coated Balloon (DCB) in the treatment of coronary artery in-stent restenosis (ISR).

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 15 sites in total · contact listed

Prospective, randomized controlled, single-blind, multicenter, clinical trial to demonstrate the safety and efficacy of the SELUTION SLR 014 PTCA DEB for treatment of de novo lesions in small coronary vessels, defined as reference vessel diameter (RVD) of 2.00 mm to 2.75 mm, in support of a pre-mark…

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 70 sites in total · contact listed

A study to evaluate the effect of abelacimab relative to placebo on the rate of ischemic stroke or systemic embolism (SE) in patients with Atrial Fibrillation (AF) who have been deemed by their responsible physicians or by their own decision to be unsuitable for oral anticoagulation therapy.

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📍 Nearest site: Hutchinson, Kansas, United States — 36 km away · 789 sites in total · contact listed

The purpose of this trial is to generate clinical evidence related to key performance outcomes of Endurant II/IIs Stent Graft Systems verses Gore Excluder / Excluder Conformable AAA Endoprosthesis in subjects with Abdominal Aortic Aneurysms. Subjects are randomized and imaging collected at all follo…

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 68 sites in total · contact listed

The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4/X4S Transcatheter Heart Valve (THV) in subjects who are at high or greater risk with a failing aortic bioprosthetic valve.

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 36 sites in total

The study is an early feasibility study to measure individual patient clinical outcomes and effectiveness, evaluate the safety and function of the DUO Transcatheter Tricuspid Coaptation Valve System (DUO System).

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 15 sites in total · contact listed

The purpose of this study is to generate clinical evidence on valve safety and performance in subjects treated by redo Transcatheter Aortic Valve Replacement (TAVR).

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 71 sites in total · contact listed

The purpose of the study is to evaluate the clinical safety and efficacy of the Prevail DCB.

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 51 sites in total · contact listed

The SuperSaturated Oxygen Comprehensive Observational Registry (SSCORE) registry, a prospectively designed observational study, aims to evaluate the clinical utility, infarct size reduction, and cost-effectiveness of SSO2 Therapy versus PCI alone among patients with anterior AMI in routine clinical practice.

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 25 sites in total · contact listed

This study will establish the safety and effectiveness of the SAPIEN M3 System in subjects with symptomatic, at least 3+ mitral regurgitation (MR) for whom commercially available surgical or transcatheter treatment options are deemed unsuitable. Following completion of enrollment, subjects will be…

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 68 sites in total

The purpose of the study is to assess the safety and efficacy of the Orsiro® Mission 48- mm Sirolimus-Eluting Coronary Stent System in the treatment of subjects with atherosclerotic lesion(s) \>36 mm and ≤ 44 mm in length (by visual estimate) in the native coronary arteries with a reference vessel d…

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 23 sites in total

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants with Uncontrolled Hypertension

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 28 sites in total

Safety and performance evaluation of the CardioMech Mitral Valve Repair System (MVRS) in patients with degenerative mitral valve regurgitation.

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 12 sites in total · contact listed

The objective of this study is to evaluate the preliminary safety and effectiveness of the Cephea Mitral Valve System for the treatment of symptomatic patients with mitral valve disease (including mitral regurgitation, mitral stenosis and mixed mitral valve disease) in whom transcatheter therapy is…

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📍 Nearest site: Wichita, Kansas, United States — 43 km away · 22 sites in total · contact listed